![]() LSZ reduced AD biomarker Aβ plaque accumulation by inhibiting β-secretase and γ-secretase gene expression. LSZ significantly improved the cognition of the mice without adverse effects, indicating its high degree of safety and efficacy after a long-term treatment. Double transgenic mice expressing the amyloid-β precursor protein and mutant human presenilin 1 (APP/PS1) to model AD were treated with LSZ for 7 months starting at 2 months of age. In this study, we aimed to determine the effect of LSZ on the AD process. LSZ contains several neuroprotective ingredients, including Hirudo, Astmgali Radix, Carthami Flos (Honghua), Persicae Semen (Taoren), Acori Tatarinowii Rhizoma (Shichangpu), and Acanthopanax Senticosus (Ciwujia). LongShengZhi Capsule (LSZ), a traditional Chinese medicine, has been approved by the China Food and Drug Administration for treatment of patients with cardiovascular/cerebrovascular disease. It may be caused by oxidative stress, inflammation, and cerebrovascular dysfunctions in the brain. 4College of Life Sciences, Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education, Nankai University, Tianjin, ChinaĪlzheimer’s disease (AD) is the most common form of dementia in the elderly.3People’s Hospital of Zunhua, Tangshan, China.2School of Biological and Pharmaceutical Engineering, West Anhui University, Lu’an, China.1Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China.Zequn Yin 1†, Xuerui Wang 1†, Shihong Zheng 1, Peichang Cao 1, Yuanli Chen 1, Maoyun Yu 2, Chenzhong Liao 1, Zhongyuan Zhang 3, Jihong Han 1,4, Yajun Duan 1, Xiaoxiao Yang 1* and Shuang Zhang 1* ![]()
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